My desired draft (or one of them:):

Round 1. Shariff Floyd, DT, Florida: At some point, San Francisco has to assume that the ageless Justin Smith might finally need a breather, and Floyd is the type of versatile defensive lineman who profiles well as a 3-4 defensive end. Florida moved Floyd to the inside during his sophomore season, but he was back at defensive end this season, and just kept getting better. Like Smith, he's a powerful player who can push the pocket with power and will free up other pass-rushers, while making tackles for loss on his own. (from Kiper)

Round 2: Barrett Jones, C/OG/OT, Alabama: As a pass protector, Jones displays a very strong anchor and is able to prevent defenders from driving him off of the ball. This would be particularly appealing to New England considering the increasing number of defenses which run three man fronts with massive nose tackles occupying the middle of the offensive line. Jones’ grip strength is impressive and he can prevent pass rushers from disengaging once he has locked on; the ability to sustain blocks is especially critical at the pro level because passing in the NFL requires quarterbacks to go through more progressions than in college. As a converted offensive tackle Jones possesses above-average mirror skills for the interior offensive line, although he fares better against power rushers than speed rushers. Jones is a very fundamentally sound player who is quick to set up in protection, makes very few mental mistakes, and understands leverage concepts. (from Patriots article)

or

Jesse Williams. Two DLs with the first two picks? Our rotation is thin, and Williams is NT size who can also play outside. A little like Soaps in that regard. He would not add a lot to the pass rush but is very good at demanding double teams and helping others.

Round 3: corner if one is worth it here and or receiver, same criteria.

Round 3 or 4: Denard Robinson, WR, Michigan: Everyone knows him as a quarterback until the last half of this year. He is a phenomenal athlete and would take some time to develop, but imagine him also as an emergency starter at QB. He could run the read-option, is very elusive, and has a solid arm. You aren't looking for someone who could challenge Kaep, but someone who could add something in certain situations or fill in if he had to.

Round 4: Marcus Lattimore, RB, South Carolina: This guy was one of the best backs in the country until two horrific knee injuries. So he would be a risk. Then again, Frank Gore had more knee injuries than that and has worked out pretty well. Worth the risk to me in the 4th, especially if we have that many picks.

Round 5: Robert Lester, FS, Alabama: very good tackler and solid in coverage. Very good depth where we a thin.